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1

Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat

Longhu Zhou, Chandar S. Thakur, Ross J. Molinaro, Jayashree M. Paranjape, Rieuwert Hoppes, Kuan-Teh Jeang, Robert H. Silverman, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1.34 MB

english, 2006

2

Summary of the results from the lunar orbiter laser altimeter after seven years in lunar orbit

Smith, David E., Zuber, Maria T., Neumann, Gregory A., Mazarico, Erwan, Lemoine, Frank G., Head III, James W., Lucey, Paul G., Aharonson, Oded, Robinson, Mark S., Sun, Xiaoli, Torrence, Mark H., Barke

Journal:

Year:

2016

Language:

english

File:

PDF, 14.72 MB

english, 2016

3

Ice & Fire: Missions to the most difficult solar system destinations… on a budget

Robert L. Staehle, Stephen C. Brewster, John B. Carraway, Alok K. Chatterjee, Karla B. Clark, Richard J. Doyle, Paul K. Henry, Jennie R. Johannesen, Torrence V. Johnson, Edward J. Jorgensen, Richard P

Journal:

Acta Astronautica

Year:

1999

Language:

english

File:

PDF, 1.41 MB

english, 1999

4

Convergent synthesis of ribonuclease L-active 2′,5′-oligoadenylate-peptide nucleic acids

Zhengfu Wang, Ling Chen, Suzanne F. Bayly, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 117 KB

english, 2000

5

Efficient Functionalization of 2‘,5‘-Oligoadenylates with Sulfur

Lesiak, Krystyna, Torrence, Paul F.

Journal:

Bioconjugate Chemistry

Year:

1997

Language:

english

File:

PDF, 139 KB

english, 1997

6

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (Torrence/Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats) || Confronting New and Old Antiviral Threats: Broad Spectrum Potential of Prenylation Inhibitors

Torrence, Paul F.

Year:

2005

Language:

english

File:

PDF, 191 KB

english, 2005

7

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (Torrence/Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats) || Discovery and Development of New Antivirals for Smallpox

Torrence, Paul F.

Year:

2005

Language:

english

File:

PDF, 298 KB

english, 2005

8

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (Torrence/Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats) || The Emergence of Pandemic Influenza A: Bioterrorist Versus Mother Nature

Torrence, Paul F.

Year:

2005

File:

PDF, 1.10 MB

2005

9

ChemInform Abstract: 2-Methyladenosine-Substituted 2′,5′-Oligoadenylates: Conformations, 2-5A Binding and Catalytic Activities with Human Ribonuclease L.

Yukio Kitade, Masaharu Wakana, Takayuki Tsuboi, Chizuko Yatome, Suzanne F. Bayly, Mark R. Player, Paul F. Torrence

Journal:

Year:

2000

File:

PDF, 26 KB

2000

10

ChemInform Abstract: Replacement of the Phosphodiester Linkage in DNA with Sulfamide and 3′-N-Sulfamate Groups.

Kevin J. Fettes, Nigel Howard, David T. Hickman, Steven A. Adah, Mark R. Player, Paul F. Torrence, Jason Micklefield

Journal:

Year:

2000

File:

PDF, 30 KB

2000

11

ChemInform Abstract: Synthesis and Nucleic-Acid-Binding Properties of Sulfamide- and 3′-N-Sulfamate-Modified DNA.

Kevin J. Fettes, Nigel Howard, David T. Hickman, Steven Adah, Mark R. Player, Paul F. Torrence, Jason Micklefield

Journal:

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

12

Accelerating RNA Decay Through Intervention of RNAse L: Alternative Synthesis of Composite 2′,5′-Oligoadenylate-antisense

Paul F. Torrence, Zhengfu Wang

Journal:

Year:

2003

File:

PDF, 53 KB

2003

13

Active Volcanism on Io as Seen by Galileo SSI

Alfred S. McEwen, Laszlo Keszthelyi, Paul Geissler, Damon P. Simonelli, Michael H. Carr, Torrence V. Johnson, Kenneth P. Klaasen, H.Herbert Breneman, Todd J. Jones, James M. Kaufman, Kari P. Magee, Da

Journal:

Year:

1998

Language:

english

File:

PDF, 2.01 MB

english, 1998

14

Assay of 2′,5′-oligoadenylate phosphodiesterase activity in mouse L-cell extracts

Paul F. Torrence, Jiro Imai, Margaret I. Johnston

Journal:

Analytical Biochemistry

Year:

1983

Language:

english

File:

PDF, 694 KB

english, 1983

15

Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser

Nancy L. Nolan-Sorden, Krystyna Lesiak, Bernard Bayard, Paul F. Torrence, Robert H. Silverman

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 1.23 MB

english, 1990

16

Incorporation of spin probes into polynucleotides by enzymatic polymerization

Albert M. Bobst, Paul F. Torrence

Journal:

Year:

1978

Language:

english

File:

PDF, 375 KB

english, 1978

17

Uridine analogs of 2′,5′-oligoadenylates: On the biological role of the middle base of 2-5A trimer

Yukio Kitade, David K. Alster, Aysun Pabuccuoglu, Paul F. Torrence

Journal:

Bioorganic Chemistry

Year:

1991

Language:

english

File:

PDF, 1.27 MB

english, 1991

18

Electrochemical study of a pyridine analog of 3′-azido-3′-deoxythymidine (AZT) related to AIDS dementia

Wiesław Kawczyński, Paul F. Torrence, Jun-ei Kinjo, Barbara Czochralska

Journal:

Bioelectrochemistry and Bioenergetics

Year:

1994

Language:

english

File:

PDF, 915 KB

english, 1994

19

Reaction intermediates of a dihydropyridine derivative of 2′,3′-dideoxycytidine related to AIDS dementia studied by laser flash photolysis

Wieslaw Kawczynski, Barbara Czochralska, Lars Lindqvist, Paul F. Torrence

Journal:

Bioelectrochemistry and Bioenergetics

Year:

1996

Language:

english

File:

PDF, 325 KB

english, 1996

20

Synthesis and antiviral activities of new acyclic and “double-headed” nucleoside analogues

Xinying Zhang, Adel Amer, Xuesen Fan, Jan Balzarini, Johan Neyts, Erik De Clercq, Mark Prichard, Earl Kern, Paul F. Torrence

Journal:

Bioorganic Chemistry

Year:

2007

Language:

english

File:

PDF, 180 KB

english, 2007

21

3-Deazaadenosine analogues of p5′A2′p5′A2′p5′A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L

Elena N Kalinichenko, Tatiana L Podkopaeva, Elena V Budko, Frank Seela, Beihua Dong, Robert Silverman, Jouko Vepsäläinen, Paul F Torrence, Igor A Mikhailopulo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 409 KB

english, 2004

22

Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro

Paul F. Torrence, Xuesen Fan, Xinying Zhang, Philippe M. Loiseau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

23

The Ugi reaction in the generation of new nucleosides as potential antiviral and antileishmanial agents

Xuesen Fan, Xinying Zhang, Christian Bories, Philippe M. Loiseau, Paul F. Torrence

Journal:

Bioorganic Chemistry

Year:

2007

Language:

english

File:

PDF, 227 KB

english, 2007

24

Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue improves the 3′-exonuclease stability of 2′-5′-oligoadenylate-antisense conjugates

Jeroen C Verheijen, Anne-Marie M van Roon, Nico J Meeuwenoord, Hanneke R Stuivenberg, Suzanne F Bayly, Ling Chen, Gijsbert A van der Marel, Paul F Torrence, Jacques H van Boom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 125 KB

english, 2000

25

Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action

Mark R. Player, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 279 KB

english, 1999

26

Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′-O-methylated 2-5A-antisense oligonucleotides

Hagen Cramer, Mark R. Player, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 378 KB

english, 1999

27

2-Methyladenosine-substituted 2′,5′-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L

Yukio Kitade, Masaharu Wakana, Takayuki Tsuboi, Chizuko Yatome, Suzanne F Bayly, Mark R Player, Paul F Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 119 KB

english, 2000

28

Probing the activation site of ribonuclease L with new N6-substituted 2′,5′-adenylate trimers

Ursula Münch, Ling Chen, Suzanne F Bayly, Paul F Torrence

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 265 KB

english, 2003

29

2′,5′-Oligoadenylate-peptide nucleic acids (2–5A-PNAs) activate RNase L

Jeroen C Verheijen, Gijsbert A van der Marel, Jacques H van Boom, Suzanne F Bayly, Mark R Player, Paul F Torrence

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 288 KB

english, 1999

30

The solid-phase synthesis of 2-5-linked oligoriboadenylates containing 8-bromoadenine

Krystyna B. Lesiak, Bogdan Uznanski, Paul F. Torrence

Journal:

Applied Biochemistry and Biotechnology

Year:

1997

Language:

english

File:

PDF, 722 KB

english, 1997

31

Evaluating Coalition Capacity to Strengthen Community–Academic Partnerships Addressing Cancer Disparities

William Alvin Torrence, Karen Hye-cheon Kim Yeary, Chara Stewart, Paulette Mehta, Kelly Duke, Nancy Greer-Williams, Jeffrey J. Guidry, Deborah Erwin, Paul Greene, Ronda S. Henry-Tillman

Journal:

Journal of Cancer Education

Year:

2011

Language:

english

File:

PDF, 137 KB

english, 2011

32

A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity

Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, Paul F. Torrence

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

33

Synthesis of a 5′-thiophosphate analogue of 2-5A, a phosphatase resistant activator of the 2-5A-dependent ribonuclease

Wei Xiao, Li Guiying, Krystyna Lesiak, Beihua Dong, Robert H. Silverman, Paul F. Torrences

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 445 KB

english, 1994

34

Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense

Douglas W. Leaman, Frank J. Longano, James R. Okicki, Kenneth F. Soike, Paul F. Torrence, Robert H. Silverman, Hagen Cramer

Journal:

Year:

2002

Language:

english

File:

PDF, 198 KB

english, 2002

35

Effect of interferon and 2′,5′-oligoadenylates on rotavirus RNA synthesis

Maritza Ríos, Marianne Muñoz, Paul F. Torrence, Eugenio Spencer

Journal:

Antiviral Research

Year:

1995

Language:

english

File:

PDF, 703 KB

english, 1995

36

Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space

Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, Paul F. Torrence

Journal:

Antiviral Research

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

37

Evaluation of synthetic oligonucleotides as inhibitors of West Nile virus replication

Paul F. Torrence, Nidhi Gupta, Carol Whitney, John D. Morrey

Journal:

Antiviral Research

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

38

Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase

Emma Harden, Kathy Keith, Mary Johnson, Alexis McBrayer, Ming Luo, Shihong Qiu, Debasish Chattopadhyay, Xuesen Fan, Paul Torrence, Earl Kern, Mark Prichard

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

39

The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation

Mark R. Player, Paul F. Torrence

Journal:

Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 7.72 MB

english, 1998

40

Interferon Induction by a 2′-Modified Double-Helical RNA, Poly(2′-azido-2′-deoxyinosinic acid) · polycytidylic acid

Erik DE CLERCQ, Paul F. TORRENCE, B. David STOLLAR, John HOBBS, Toshikazu FUKUI, Nobuko KAKIUCHI, Morio IKEHARA

Journal:

Year:

1978

Language:

english

File:

PDF, 787 KB

english, 1978

41

Conformational analysis of brominated pA2′-5′A2′-5′A analogs : An NMR and model-building study

Yvonne Th. van den HOOGEN, Coen M. A. HILGERSOM, Danuta BROZDA, Krystyna LESIAK, Paul F. TORRENCE, Cornelis ALTONA

Journal:

Year:

1989

Language:

english

File:

PDF, 808 KB

english, 1989

42

Dissection of the Roles of Adenine Ring Nitrogen (N-1) and Exocyclic Amino (N-6) Moieties in the Interaction of 2-5A with RNase L

Mark R. Player, Elena N. Kalinichenko, Tatjana L. Podkopaeva, Igor A. Mikhailopulo, Frank Seela, Paul F. Torrence

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 537 KB

english, 1998

43

Ribonuclease L, a 2-5A-Dependent Enzyme: Purification to Homogeneity and Assays for 2-5A Binding and Catalytic Activity

Mark R. Player, Ewald M. Wondrak, Suzanne F. Bayly, Paul F. Torrence

Journal:

Year:

1998

Language:

english

File:

PDF, 655 KB

english, 1998

44

Polynucleotide duplexes based on poly(7-deazaadenylic acid)

Paul F. Torrence, Bernhard Witkop

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1975

Language:

english

File:

PDF, 545 KB

english, 1975

45

The interaction of polyxanthylic acid with polyadenylic acid

Paul F. Torrence, Erik De Clercq, Bernhard Witkop

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1977

Language:

english

File:

PDF, 328 KB

english, 1977

46

Phosphorylation of 2-5A core 5′-diphosphate to 2–5 a in mouse L cell extracts

Krystyna Lesiak, Paul F. Torrence

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 290 KB

english, 1985

47

Antiviral and antimetabolic activities of poly (7-deazaadenylic acid) and poly(7-deazainosinic acid)

Erik De Clercq, Alfons Billiau, Paul F. Torrence, James A. Waters, Bernhard Witkop

Journal:

Biochemical Pharmacology

Year:

1975

Language:

english

File:

PDF, 646 KB

english, 1975

48

2-fluorohistidine—Effects on protein synthesis in cell-free systems and in mouse L cells

Paul F. Torrence, Robert M. Friedman, Kenneth L. Kirk, Louis A. Cohen, Cyrus R. Creveling

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 368 KB

english, 1979

49

5-substituted 2′-deoxyuridines: Correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase

Jan Balzarini, Erik De Clercq, Mathias P. Mertes, David Shugar, Paul F. Torrence

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 752 KB

english, 1982

50

Activation of human and mouse 2-5A synthetases and mouse protein P1 kinase by nucleic acids: Structure-activity relationships and correlations with inhibition of protein synthesis and interferon induction

Paul F. Torrence, Margaret I. Johnston, David A. Epstein, Helmut Jacobsen, Robert M. Friedman

Journal:

Year:

1981

Language:

english

File:

PDF, 477 KB

english, 1981

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